Clinical Trial #: PAN009-18 The previous generation of SAPIEN valves, SAPIEN XT, was approved for commercial use by the FDA for a failed surgical bioprosthetic aortic valve in October 2015. Learn more at Clinicaltrials.gov. diabetes in individuals experiencing hypoglycemia unawareness and severe hypoglycemic Previous research has found that this ongoing pain may, in part, be caused by problems in the way the brain processes pain signals. Talk with your doctor to decide if a clinical trial is right for you. This is called pain centralization. Clinical Trial #: A011801 22-011 However, little is currently known about why or how that chamber of the heart becomes dysfunctional in patients with this condition. Learn more at Clinicaltrials.gov, Study: (PDIGEE) PD-Inhibitor (Nivolumab) and Ipilimumab Followed by Nivolumab vs. VEGF TKI Cabozantinib with Nivolumab: A Phase III Trial in Metastatic Untreated Renal Cell Cancer Principal Investigator: Dr. Magill In large vessel vasculitis, blood vessels such as the temporal arteries that run along the sides of the head can become . Principal Investigator: Dr. Shenoy Clinical Trial #: S1931 Learn more at Clinicaltrials.gov, Study: Phase III Randomized Trial Comparing Overall Survival After Photon Versus Proton Chemoradiotherapy for Inoperable Stage II-IIIB NSCLC. Heart Failure is a condition that makes the heart muscle weak and the heart cannot pump as much blood as the body needs. Contact: Research Office 630.933.7820 Participants will be in this research study for one study visit, lasting about 2 hours. Wear a device to monitor sleep and activity until week 28. Use adequate birth control measures for the duration of the study. A subset of patients who are interested and eligible will undergo a brain MRI at baseline and the 12-month study visit. We will also determine whether telmisartan plus supervised exercise improves walking performance more than telmisartan alone and more than supervised treadmill exercise alone. There are several forms of AF. Principal Investigator: Dr. Dawravoo We would like to investigate the role of macrophages and other important cells in the development of ILD. Principal Investigator: Robert Eisner, DO Clinical Trial #: EAA181 Principal Investigator: Dr. Gondi Additionally, the main research study will provide preliminary information regarding tolerability and safety of mavacamten treatment in HFpEF. Contact: Research Office 630.933.7820 Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta Principal Investigator: Dr. Chawla Contact: Research Office 630.933.7820 Blood specimens from patients with breast cancer will be collected and utilized for future research projects known as biomarker studies. This tumor may , The purpose of this research is to determine whether radiotherapy after surgery to remove a breast cancer can help decrease the number of circulating tumor cells (CTCs) in the blood. NCT#: NCT05438212 Contact: Research Office 630.933.7820 At least one of the following (summarized in checklist below): o one (1) swollen metacarpophalangeal (MCP) or proximal interphalangeal (PIP) joint and any one (or more) of the following: Patients who participate will attend 3 clinic visits and 2 phone calls over 45 days and will complete the following: A stipend will be offered to participants for each completed study visit. Learn more at Clinicaltrials.gov, Study: OVarian Suppression Evaluating Subcutaneous LeuprolIde Acetate in Breast Cancer (OVELIA): A Phase 3, Single Arm, Open-Label Study Evaluating Ovarian Suppression Following Three-Month Leuprolide Acetate For Injectable Suspension (TOL2506) in Combination with Endocrine Therapy in Premenopausal Subjects with Hormone-ReceptorPositive (HR+), Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Breast Cancer. After transplantation, or any other major surgery, there will be inflammation in the body. (Clinical Trial) Estimated Enrollment : 53 participants: Allocation . This study will help the study doctors find out if this different approach is better than the usual approach. This study will also identify biomarkers that could provide insight into targeted therapies for future clinical trials. Principal Investigator: Dr. Chawla The purpose of this study is to determine whether drinking daily cocoa-enriched beverages improves walking performance in people with PAD. In healthy people, . Contact: Research Office 630.933.7820 Contact: Research Office 630.352.5362 Despite recent drug approvals for HCC, it has become clear that only , The purpose of this study is to find out the relationship between kidney function and safety and pharmacokinetics of the study drug. If receiving biologic DMARDs, must be on a stable dose for at least 60 days. This is called pain centralization. Mavacamten is an investigational drug. Participants can enroll in any number of research studies designed to help us . NCT#:NCT04478279 In 2022, we led 6,093 clinical trials for 315,720 study participants. Contact: Research Office 630.933.7820 The purpose of the study is to: Collect clinical data and genetic information (DNA) on patients with vasculitis; Discover genetic markers that increase the risk of developing vasculitis; Discover genetic markers linked with certain symptoms of vasculitis. Learn more at Clinicaltrials.gov2, Study: A Phase I study of Safety and Tolerability of Acetazolamide with Temozolomide in Adults with Newly Diagnosed MGMT Promoter-Methylated Malignant Glioma Learn more at Clinicaltrials.gov, Study: A Phase II Trial of Escalated Dose Proton Radiotherapy with Elective Nodal Irradiation and Concomitant Chemotherapy for Patients with Unresectable, Borderline Resectable or Medically Inoperable Pancreatic Adenocarcinoma NCT Number: NCT02201992 The findings demonstrate that the transcription factor hepatocyte nuclear factor 4 alpha (HNF4A) regulates bone frailty and is implicated in the . Learn more at Clinicaltrials.gov, Study: Chemoradiotherapy with or w/o Atezolizumab in Treating Patients with Localized Muscle Invasive Bladder Cancer. Principal Investigator: Dr. Mulcahy Questions About Volunteering in a Clinical Trial. NCT#: NCT02775383 Shruti Gupta and David Leaf at Brigham and Womens Hospital, has the goal of collecting data on over 300 ICI-associated acute kidney injury cases from more than 30 academic medical centers worldwide. Finding safe and effective ways to prevent cancer is a partnership between researchers, who design clinical trials, . NCT Number: NCT05327686 We will collect skin, esophageal and stomach biopsies (small pieces of tissue) to be used for several studies.. NCT#: NCT04423211 Learn more at Clinicaltrials.gov, Study: A Phase II Randomized Trial of Cabozantinib (NSC #761968) with or Without Atezolizumab (NSC #783608) in Patients with Advanced Papillary Renal Cell Carcinoma (PAPMET2) The study device is a bioprosthetic heart valve made out of man-made materials and animal tissue. Macitentan 10 mg once-daily is approved in many countries around the world for the treatment of pulmonary arterial hypertension (PAH). NCT Number: NCT03267433 The purpose of the ENRGISE Pilot Study is to look at the effect of anti-inflammatory drugs on physical functioning in older adults. In another chamber of the heart, the left ventricle, it is known that elevated blood pressure in that chamber causes the development of diffuse fibrosis, or scarring between the muscle fibers, and a similar process may take place in the right ventricle of patients with CTEPH. Participation involves approximately 10 study visits: every 3 months for the first year, every 6 months until the end of year 2, and at year 3, year 4 and year 5. This build up is called an amyloid deposit. If you are eligible for a proton therapy clinical trial as a patient at the Proton Center, someone from our team will likely reach out to you to communicate the details of the study. Contact: Research Office 630.933.7820 A clinical trial may test a medicine, a procedure, or a device to see if it works and is safe. cerebrovascular accident including transient ischemic attacks within 3 months of Lumason administration), Clinical signs of acute rejection as the indication for transplant kidney biopsy, Inability for patient or patients surrogate to provide informed consent. This study is recruiting patients with a diagnosis of hypertrophic cardiomyopathy (HCM) who are able to perform a treadmill cardiopulmonary exercise test. NCT Number: NCT04233866 Learn more at Clinicaltrials.gov, Study: Evaluation tracking project: a prospective chart review of patients treated with proton therapy. We will characterize the clinical features of ICI-associated AKI in the hope that this will help us to determine predictors of toxicity and best practices for management. This study includes two in-person study visit to complete quantitative sensory testing (QST), blood draws, joint counts, blood pressure assessment, and patient-reported outcome (PRO) questionnaires. Approximately 300 patients, at 75 study centers, will be enrolled in FALCON around the world. Galter Pavilion675 N. St. Clair, 21st FloorChicago, IL 60611, 303 E. Superior L3 - 125Chicago, Illinois 60611, Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center of Northwestern University Home, Comprehensive Neuroendocrine Tumor Program, For Clinicians, Scientists & Students Overview, Robert H. Lurie Comprehensive Cancer Center of Northwestern University. Previous research has found that this ongoing pain may, in part, be caused , This study will evaluate the safety and effectiveness of the SetPoint Medical System (study device) for the treatment of patients with active, moderate-to-severe rheumatoid arthritis (RA), who have had an inadequate response or intolerance to biologic or targeted synthetic Disease Modifying Anti-Rheumatic Drugs (DMARDs)., Starzl Academy for Physician-Scientist Training, Endocrinology, Metabolism and Molecular Medicine, chronic thromboembolic pulmonary hypertension, Transcatheter Aortic Valve Replacement (TAVR), Transthyretin-Mediated Amyloid Cardiomyopathy, Heart failure with Preserved Ejection Fraction, Heart Failure with Reduced Ejection Fraction, Serial Monitoring of Circulating Tumor Cells During Radiotherapy for Women with Non-Metastatic Breast Cancer: A Prospective Observational Cohort Study, MSM; HIV Positive and Negative; Long-Term Study; Aging Study, primary focal segmental glomerulosclerosis, autosomal dominant polycystic kidney disease, neuropsychiatric systemic lupus erythematosus, Diagnosis of interstitial lung disease (ILD), Receives care at Northwestern's Pulmonary Clinic, donate fluid collected from their lungs during a bronchoscopy (taken at the time they are already scheduled to have a bronchoscopy or during their scheduled endoscopy), give esophageal biopsies (taken during their scheduled endoscopy), Receive care at Northwestern Medicine in Rheumatology, Pulmonary & Critical Care, and/or Gastroenterology scleroderma clinics, Plan to undergo a standard of care bronchoscopy or endoscopy at Northwestern or a research bronchoscopy through a separate Northwestern study, Randomly assigned to macitentan 75 mg or placebo. Principal Investigator: Dr. George Contact: Research Office 630.933.7820 The purpose of this study is to assess the safety and effectiveness of the AccuCinch Ventricular Restoration System and compare it to standardized heart failure medications. Clinical Trial #: EA2182 Normally, white blood cells are produced in a controlled way by the bone marrow. Clinical trials have played an important role in the fight against cancer. However, relapse after treatment remains a problem, and can be as high as 80% in some types of AML patients. NCT Number: NCT03793166 We are trying to find out if a lifestyle program that promotes modest weight loss and increased physical activity will improve COPD symptoms for those with a high BMI. We are conducting the INSIGHT COPD study because symptoms of chronic obstructive pulmonary disease (COPD) and high body mass index (BMI) overlap. This study will , This study will examine different proteins and cell types in blood and cerebrospinal fluid (CSF) of patients with systemic lupus (SLE) who may or may not currently be experiencing neuropsychiatric manifestations of the disease. To improve the understanding of factors associated with the atrial myopathy in people with AF or people at risk for developing AF, The objectives of this pivotal clinical trial are to evaluate the safety and effectiveness of the PASCAL System for transcatheter mitral valve repair compared to the MitraClip system in the treatment of patients with symptomatic degenerative mitral regurgitation (DMR) and who have been determined to be at prohibitive risk for . Principal Investigator: Dr. Jochen Lorch NCT#: NCT04316117 Principal Investigator: Kevin Dawravoo, MD Clinical Trial #: NRG-CC009 NCT Number: NCT04340141 Almost every cancer treatment that is saving lives today is the result of a clinical trial. Contact: Research Office 630.933.7820 Clinical Trial #: EAA173 Heart failure (HF) and chronic kidney disease (CKD) commonly coexist and increase risks of hospitalizations and mortality. This study will evaluate the safety and effectiveness of the Edwards SAPIEN 3 Transcatheter Heart Valve (THV) Model 9600TFX and associated delivery systems for the aortic valve in valve procedure. In addition to the therapeutic clinical trials you can find above, Lurie Cancer Center offers access to clinical trials studying new ways to prevent cancer and detect it early, new approaches to medical, surgical and radiation therapy, advanced technologies and effective ways to improve quality of life. Learn more at Clinicaltrials.gov, Study: Phase III Trial of Immunotherapy-Based Combination Therapy with or Without Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma (Probe Trial) We are trying to find . This study is recruiting patients aged 18-80 years and who have been diagnosed with dilated cardiomyopathy due to a mutation in either MYH7 or TTN, both of which are genes involved in the function of heart muscle. FALCON is a Phase 3 clinical study evaluating the effectiveness and safety of bardoxolone methyl (an oral investigational drug) in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). Robert H. Lurie Comprehensive Cancer Center of Northwestern University Clinical Cancer Center. The purpose of this study is to determine whether drinking daily cocoa-enriched beverages improves walking performance in people with PAD. Brief Summary: This study is an open-label, international, multi-center, Phase 2 study in adult patients with recurrent, locally-advanced or metastatic solid tumors, which harbor the NRG1 gene fusion. Clinical Trials In 2022, we led 6,093 clinical trials for 315,720 study participants. This study will help the study doctors find out if this different treatment (chemotherapy plus nivolumab) is better, the same, or worse than the usual approach of chemotherapy alone. NCT #: NCT03180502 Principal Investigator: Dr. Mihalcik Principal Investigator:Dr. Gondi Clinical Trial #: NU 21C01 Previous studies have shown that cocoa may improve blood flow, improve cardiovascular health, and improve muscle function and strength. The purpose of Phase 1 , The purpose of this study is to compare the early treatment(before you have symptoms) of venetoclax and obinutuzumab (V-O) to the usual treatment of V-O after you have symptoms. NCT #: NCT03115333 Clinical Trial #: EAF151 20-062 However, there is evidence that in people with scleroderma, the macrophages behave abnormally and contribute to scarring in the lungs. To date, NCPC trials, 19 in total, have accrued 534 patients (354 from the 2003 consortium and . Learn more at Clinicaltrials.gov, Study: A Randomized Phase II Trial of Triplet Therapy (a PD-L1 Inhibitor Durvalumab (MEDI4736) in Combination with Olaparib and Cediranib) Compared to Olaparib and Cediranib or Durvalumab (MEDI4736) and Cediranib or Standard of Care Chemotherapy in Women with Platinum-Resistant Recurrent Epithelial Ovarian Cancer, Primary Peritoneal or Fallopian Cancer Who Have Received Prior Bevacizumab Researchers want to know if using clindamycingel and triamcinolone topical (on the skin) lotion , The purpose of this study is to assess if the use of a 3D imaging device called the Clarix Imaging Volumetric Specimen Imager (VSI) can help guide and assist surgeons in identifying and removing all positive margins while in the operating room for breast conservation surgery.If you are undergoing , This study is being done to collect, process, and store blood samples of plasma cell disorder patients. Learn more at Clinicaltrials.gov, Study: Phase III Trial of Stereotactic Radiosurgery (SRS) versus Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for 10 or fewer Brain Metastases from Small Cell Lung Cancer This study is enrolling patients who have transthyretin-mediated amyloid cardiomyopathy (ATTR-CM) which is a disease caused by change in a protein called transthyretin (TTR). This study is enrolling patients who have transthyretin-mediated amyloid cardiomyopathy (ATTR-CM) which is a disease caused by change in a protein called transthyretin (TTR). Northwestern Medicine offers clinical studies right in your community for a wide variety of types and stages of cancer. This study is recruiting patients with a diagnosis of hypertrophic cardiomyopathy (HCM) who are able to perform a treadmill cardiopulmonary exercise test. The major purpose of this study is to determine the highest dose of Q702 that does not result in severe side effects, the dose that is tolerated, and once this dose is found, if it has any effect against the cancer in patients with solid cancer tumors. Volunteer today! Clinical Trial #: PARTIQoL There are several forms . To find the highest dose of Q702 that can be given without causing serious side effects when treatment is given every day for 7 days, followed by 7 days of no treatment, repeated two times during a 28-day cycle. This study is recruiting patients who have a Medtronic Reveal LINQ or LINQ II (or other market-released model) Insertable Cardiac Monitor (ICM) device to monitor their Atrial Fibrillation (Afib). We are also looking at the effects on shortness of breath, quality-of-life, and cardiovascular disease risk factors. Contact: Research Office 630.933.7820 Principal Investigator: Dr. Gondi Clinical Trial #: N0577 Researchers conduct studies to learn more about scleroderma, understand why the skin and other internal organs become thickened and hardened (fibrotic) in people with scleroderma, and determine what therapies are effective for treating scleroderma. Clinical Trial #: A021502 Previous research has found that this ongoing pain may in part be caused by problems in the way the brain processes pain signals. Diagnosis of newly diagnosed GBM or any malignant glioma with plan to initiate treatment with TTFields with or without systemic therapy, confirmed by the enrolling institution, Able to self-administer topical interventions or has available another person who can apply the topical agents, Treatment with TTF should be initiated within 7 days of planned initiation in this trial, The studys purpose is to measure blood flow to and from the kidney via contrast-enhanced ultrasound (contrast agent, Lumason, is given via IV administration), Participation consists of 5 study visits that are spread out over the course of 24 months (Healthy and ESRD participants only complete the first 2 study visits), Study procedures consist of measuring height, weight, and vital signs, answering questions about demographics and medical history, a blood draw and urine collection at every visit, and undergoing the contrast-enhanced ultrasound (only at visit 2), Patient is able to provide written informed consent. GDX012 is a novel cell therapy developed for the treatment of certain types of cancer, including Acute Myeloid Leukemia (AML). Clinical Trial #: NRG-BN009 Participants will receive $50 for the completion of each study visit and an additional $100 for completing each MRI. of the Robert H. Lurie Comprehensive Cancer Center Northwestern University Olson Pavillion, 710 North Fairbanks Court, Chicago 8th Floor, Room 8-419 312.908.5546 FAX: 312.503.1148 Quick Links. Learn more at Clinicaltrials.gov, Study: A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients with Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer Principal Investigator: Dr. Thukral This study is recruiting patients with Tricuspid Regurgitation (TR), a condition in which the hearts tricuspid valve does not close tightly which causes the blood to flow in the wrong direction during part of the cardiac cycle (heart beat). NCT Number: NCT04216290 Contact: Research Office 630.933.7820, Study: A Randomized Phase II/III Open-Label Study of Ipilimumab and Nivolumab Versus Temozolomide in Patients With Newly Diagnosed MGMT (Tumor O-6-Methylguanine DNA Methyltransferase) Unmethylated Glioblastoma This study will help the study doctors findout if this different approach is better than the usual approach. This represents the accumulation of new cells and tissue. Contact: Research Office 630.933.7820 This irregular heart rhythm is also known as atrial fibrillation, or AF. Learn more at Clinicaltrials.gov2, Study: Phase III Trial of Observation versus Irradiation for a Gross Totally Resected Grade II Meningioma The AccuCinch Ventricular Restoration System is an investigational (experimental) device intended to treat patients who are experiencing symptoms of heart failure due to . Learn more at Clinicaltrials.gov, Study: A Phase II/III Study of Paclitaxel/Carboplatin Alone or Combined with Either Trastuzumab and Hyaluronidase-oysk (HERCEPTIN HYLECTA) or Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf (PHESGO) in HER2 Positive, Stage I-IV Endometrial Serous Carcinoma or Carcinosarcoma. (ACTIVE, NOT RECRUITING)This is a randomized, multicenter, double-blind, parallel, active-control study. Participants will also be excluded from continuing in the study if the pre-exercise echocardiogram demonstrates a reduced ejection fraction 50% or hemodynamically significant valvular disease at the baseline study visit. Learn more at Clinicaltrials.gov, Study: A multi-center registry of pediatric patients treated with proton radiation therapy. NCT#: NCT05417282 To decide if it is better, the study doctors will be , Participants 18 years or older who have metastatic melanoma, and the cancer has a change in the gene called the BRAF, and is not responsive to treatment with MEK and BRAF inhibitors will be enrolled. Clinical Trials As part of an academic medical center, the Department of Medicine at Northwestern University Feinberg School of Medicine aims to improve the human health through scientific research. Northwestern Medicine investigators have discovered that the overexpression of a transcription factor prevented bone loss in mouse models of chronic kidney disease, according to a recent study published in the Journal of Clinical Investigation.. Macitentan 10 mg once-daily is approved in many countries around the world for the treatment of pulmonary arterial hypertension (PAH). Approximately 300 patients, at 75 study centers, will be enrolled in FALCON around the world.. We want to learn more about the factors that predict how patients disease might progress over time and what their response to treatment might be. Insights into mechanisms of concurrent HF and CKD are urgently needed to improve outcomes. Finding a way to reduce pain is consistently named as one of the top priorities for patients with RA. Contact: Research Office 630.933.7820 Patients with well-. Principal Investigator: Dr. Sean Sachdev This study is recruiting patients who are scheduled to have a heart procedure called a Percutaneous Coronary Intervention (PCI) and may be at risk of potential problems during the procedure because they have complex heart disease and reduced left heart function. This change can either be sporadic which is known as wild-type (wtATTR-CM) or due to a mutation of the TTR gene which . Principal Investigator: Emily Hinchcliff Clinical Trial #: A031704 Learn more at Clinicaltrials.gov, Study: Phase III Intergroup Study of Radiotherapy with Concomitant and Adjuvant Temozolomide versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients with 1p/19q Co-deleted Anaplastic Glioma or Low Grade Glioma The objective of this study is to assess whether providing caregivers of older adults proxy access to an electronic patient portal (MyChart) improves the outpatient medication safety and communication between caregivers and health care providers. ION-682884 is an investigational drug. NCT#: NCT04248452 Meet criteria for rheumatoid arthritis (RA) and have active disease. The investigators aim to establish a NCT #: NCT05040360 The TTFields device uses low-intensity electrical fields totreat cancer, and this type of therapy can cause skin side effects, such asitching, sores, or infections. Principal Investigator:Dr. Alter This study is being done to study two investigational drugs called pembrolizumab and goserelin to see if they shrink your cancer or stop it from growing. These drugs are already approved by the FDA for use in , Hepatocellular carcinoma (HCC) is the most common form of liver cancer, making up approximately 90% of all liver cancers. The information collected is used for studies designed to increase our understanding about the course of the disease and the care and outcomes of scleroderma patients. Learn more at Clinicaltrials.gov, Study: A Phase III Study of Consolidative Radiotherapy in Patients with Oligometastatic HER2 Negative Esophageal and Gastric Adenocarcinoma (EGA) Contact: Research Office 630.933.7820, Study: A Phase 2, single arm, open label trial Combining Optune with concurrent Bevacizumab in the setting of Recurrent or Progressive Meningioma Principal Investigator: Dr. George Clinical Trial #: GY018 The Cardioband Implant will be positioned around the tricuspid valve and will be adjusted to reduce the size of the valve, thus improving the tricuspid regurgitation. A Long-Term Non-Interventional Registry to Assess Safety and Effectiveness of HUMIRA (Adalimumab) in Patients with Moderately to Severely Active Ulcerative Colitis (LEGACY), A Long-Term Non-Interventional Registry to Assess Safety and Effectiveness of HUMIRA (Adalimumab) in Patients with Moderately to Severely Active Ulcerative Colitis (LEGACY), This study is being done to compare how the esophagus and upper stomach work in people who have Scleroderma with symptoms of reflux disease or difficulty swallowing (dysphagia) to healthy controls. NCT #: NCT04396860 NCT #: NCT05411081 There are many medications for patients with COPD, but there is little mention of weight loss as a possible treatment in current research. The purpose of this study is to investigate the roles that specific cells in the immune system and their signals play in large vessel vasculitis (giant cell arteritis, GCA). Treatment sites: head & neck, thorax, pelvis, abdomen, extremities. What are Clinical Trials? With this information, researchers will conduct studies to learn more about the subtypes of head and neck cancers and determine , This study is being done to help improve the knowledge on the biology of breast cancer in the future. Many of today's standard treatments for cancer are based on earlier clinical trials. Clinical Trials We're committed to providing the most advanced treatments available for patients with brain and spine tumors, and to developing clinical research that will lead to tomorrow's standard of care. Clinical Trial #: NRG-GY012 N1 - Funding Information: Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under award number U10CA180882 (to the Alliance for Clinical Trials in Oncology Statistics and Data Management Center Health). Contact: Research Office 630.933.7820 However, it is not known if ION-682884 will help cardiomyopathy. Since 2011, six immune checkpoint inhibitors (ICIs), a type of immunotherapy, have been approved by the Federal Drug Administration for use in patients with cancer. Amyloid deposits can sometimes cause heart disease or neuropathy (nerve damage). This combination of drugs has been tested in animals, but has not been tested in people and is not approved by the FDA for treatment of , The purpose of this study is to compare the usual treatment of chemotherapy and radiation to adding MEDI4736 (durvalumab) immunotherapy to the usual treatment. Identify which patients require early and aggressive intervention and which patients are better suited for watchful waiting. This phase II trial studies whether adding pembrolizumab to olaparib (standard of care) works better than olaparib alone in treating patients with pancreatic cancer with germline BRCA1 or BRCA2 mutations that has spread to other places in the body (metastatic). Therefore, it would be beneficial to , Researchers would like to create a bio-specimen bank of tissue, blood, urine and saliva, which would then be used to study cancer and find better ways to detect, prevent, diagnose, treat and provide better care for future patients. The CONQUER Registry will enable researchers to: 2. High through-put genomic analysis associated with genetic and biomarker testing will serve to identify key potential therapeutic targets for DKD by comparing patients with rapid and slow progression patterns. Clinical Trial #: EA8185 Treatments developed through trials may be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. Principal Investigator: Dr. Fenton ION-682884 reduces the level of TTR in the blood of animals and healthy volunteers tested to date. Contact: Research Office 630.933.7820 Search above to find clinical trials offered at the Robert H. Lurie Comprehensive Cancer Center, visit our About Clinical Trials page page to learn more and talk with your doctor to decide if a clinical trial is right for you. We will compare the gene expression in patients with vasculitis to the gene expression in people without vasculitis to determine what goes wrong in patients with this condition. Clinical Trial #: CCTG MA.39 CTEPH is high blood pressure in the arteries in the pulmonary system (lungs) caused by clots. Hospitalized adults (>18 years) with symptoms suggestive of COVID-19, Illness of any duration and laboratory-confirmed SARS-CoV-2 infection within 14 days, Requires low or high flow oxygen devices or non-invasive mechanical ventilation, Has not received 5 or more doses of remdesivir as treatment for COVID-19, Has not receive 6mg or more of dexamethasone in one day, on more than one day in the past 7 days. . We aim to identify specific factors that affect the regulation of genes to help explain what goes wrong in systemic lupus. The active control is irbesartan. The purpose of this study is to compare theusual treatment alone to adding immune system activating therapy, Pembrolizumab(MK-3475), to the usual treatment. NCT #: NCT03180268 The doctors want tosee if less frequent monitoring is better or worse than more frequentmonitoring for patients with pancreatic cysts. Search Studies Search open clinical trials at Northwestern University Feinberg School of Medicine by department, condition or treatment in the bar above or view common searches below. Learn more at Clinicaltrials.gov, Study: A registry of prostate cancer patients participating in a research study to learn how genetic differences can affect patient outcomes (PROMISE) NCT Number: NCT04671667 We know that in rheumatoid arthritis (RA), considerable thickening of the lining layer (synovium) in the joints occurs. This study is recruiting patients whose medical tests show they have heart failure, and whose doctors have determined that they would benefit from an insertable cardiac monitor (ICM). The purpose of this study is to better understand the development and progression of scleroderma-related lung fibrosis (SSc-ILD). The imaging results will also be compared to the different types of cells present in the joints affected by RA. Participants will be followed longitudinally with annual blood/urine collection to better understand the causes of disease, response to therapy, and disease progression. Principal Investigator: Dr. George This study will identify factors that lead to the development of pain centralization, so that in future studies we can learn more about how to prevent the development of this kind of chronic pain in RA. Sarbajit Mukherjee, MD, MS. Roswell Park Comprehensive Cancer Center. Patients who participate in this research will: Participants will be given a stipend after the samples (blood and biopsy) have been collected. Clinical Trial #: NRG-GY019 Clinical trials are done to find out if new cancer treatments are safe and effective or better than the standard treatment. Clinical Trial #: RTOG3510/PCORI At least 18 years of age or older at the time of RA diagnosis. In patients with CTEPH symptoms of heart failure commonly result from dysfunction (not working correctly) in the right ventricle (RV), or the chamber of the heart that pumps blood to the lungs. COVID-19 has impacted the health and wellbeing of billions around the world. Over time . Clinical Trial #: S2007 This study is recruiting patients who have been diagnosed with Heart Failure with Preserved Ejection Fraction. Clinical Trial #: S1609 Participants in this study will have the investigational (experimental) Edwards SAPIEN 3 transcatheter aortic heart valve (study device) to replace . Evaluate the response in the real world (as opposed to the controlled and constrained setting of a clinical trial) to therapeutic agents and to combinations of therapeutic agents. Tissues from patients (with cancer as well as from those , In this research project, samples of blood and bone marrow will be studied in the laboratory to learn more about the nature of chronic myelogenous leukemia (CML) cells and how various medications and chemical agents affect them.The purpose of this study is to learn about how CML leukemia cells , In this research study, samples of bone marrow or peripheral blood will be collected from patients with chronic myeloid leukemia (CML) to learn more about the effect of some new drugs on CML cells in the laboratory. Learn more at Clinicaltrials.gov, Study: PRAGMATIC PHASE III RANDOMIZED TRIAL OF PROTON VS. PHOTON THERAPY FOR PATIENTS WITH NON-METASTATIC BREAST CANCER RECEIVING COMPREHENSIVE NODAL RADIATION: A RADIOTHERAPY COMPARATIVE EFFECTIVENESS (RADCOMP) CONSORTIUM TRIAL A clinical trial is a research study that's done to test a new type of prevention or treatment. For best results, use specific search terms (e.g., "glioblastoma" instead of "brain tumor"). Up to 15 patients will be enrolled in this study at up to 15 sites. These medications have been demonstrated to have great promise for treating a variety of cancers. The study involves donating one tube of blood for the collection of genetic information (DNA) at one study visit. . Clinical Trial #: NRG GI005 This study is recruiting patients who have been diagnosed with Heart Failure with Preserved Ejection Fraction. Principal Investigator: Dr. Gondi Clinical Trial #: EA8191 Participants must have a diagnosis of histologically/pathologically confirmed Stage IIIA or Stage IIIB colon adenocarcinoma, This is a long term study to look at the comprehensive health and well-being of men who have sex with men (MSM). Principal Investigator: Dr. David VanderWeele Clinical Trial #: MTG joints and blood of patients with RA. Principal Investigator: Dr. Gondi There is no study drug/intervention., Since 2011, six immune checkpoint inhibitors (ICIs), a type of immunotherapy, have been approved by the Federal Drug Administration for use in patients with cancer. FALCON is a Phase 3 clinical study evaluating the effectiveness and safety of bardoxolone methyl (an oral investigational drug) in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). In conjunction with the Lurie Cancer Center's Clinical Trials Office (CTO), the Pathology Core Facility's Clinical Trials Unit . Learn more at Clinicaltrials.gov, Study: A Phase II Trial of Sacituzumab Govitecan (IMMU-132) (NSC #820016) for Patients with HER2-Negative Breast Cancer and Brain Metastases Learn more at Clinicaltrials.gov, Study: Randomized Phase II Stereotactic Ablative Radiation Therapy (SABR) for Metastatic Unresected Renal Cell Carcinoma (RCC) Receiving Immunotherapy (SAMURAI) This study will also search for biomarkers (substances that can be measured in the blood) that may be associated with pain centralization, so that we can determine who may be at at risk for developing this kind of chronic pain and how to treat and/or prevent it in the future. Our partner Robert H. Lurie Comprehensive Cancer Center provides nationally recognized cancer care through groundbreaking clinical trails. , This study is enrolling patients who have been diagnosed with chronic thromboembolic pulmonary hypertension (CTEPH) and who are scheduled for a pulmonary endareterectomy (PEA) or balloon pulmonary angioplasty (BPA) procedure for treatment. Principal Investigator: Dr. Abad These medications have been demonstrated to have great promise for treating a variety of cancers. Brief Summary: This Phase III Trial evaluates whether breast conservation surgery and endocrine therapy results in a non-inferior rate of invasive or non-invasive ipsilateral breast tumor recurrence (IBTR) compared to breast conservation with breast radiation and endocrine therapy. The Registry will also be used to determine who might be eligible for and interested in participating in future studies related to ILD. This trial is being done to determine the ability of technetium Tc 99m tilmanocept (study drug) to find inflammatory cells in the joints of patients with rheumatoid arthritis (RA) via imaging. NCT Number:NCT04095364 Clinical Trial #: NU 16C02 Learn more at Clinicaltrials.gov2, Study: Phase III Trial of Salvage Stereotactic Radiosurgery (SRS) or SRS + Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for First or Second Distant Brain Relapse After Upfront SRS With Brain Metastasis Velocity >/= 4 Brain Metastases/Year Principal Investigator: Dr. Eisner These research studies are designed to test new ways to diagnose, treat and prevent cancer, as well as to manage symptoms and side effects of the disease. NCT Number: NCT02598349 NCT#: NCT02847559 Over time the clots typically leave scar tissue (fibrosis) in the arteries and lead to poor blood supply to the heart. Principal Investigator: Sean Sachdev ACTT-4 will evaluate the combination of baricitinib and remdesivir compared to dexamethasone and remdesivir in adult patients hospitalized with COVID-19 and requiring supplemental oxygen administered by low flow, high flow, or non-invasive mechanical ventilation. This study is being done: The purpose of this study is to compare the usual treatment of SRS alone to SRS plus HA-WBRT (whole brain radiation therapy with hippocampus avoidance) and memantine for patients with cancer that has spread to the brain and come back in other areas of the brain after earlier treatment , The purpose of this study is to compare the usual treatment (chemotherapy) alone to using nivolumab plus the usual treatment. Learn more at Clinicaltrials.gov, Study: A Phase II Randomized Trial of Adjuvant Therapy with Pembrolizumab After Resection of Recurrent/Second Primary Head and Neck Squamous Cell Carcinoma with High Risk Features The intent is to collect, process, and study kidney tissue and to harvest blood, urine and genetic materials to elucidate molecular pathways and link them to biomarkers that . We hope that the program will lead to weight loss and better exercise tolerance. Contact: Research Office 630.933.7820 The collected blood samples will be used for research projects to study the abnormal plasma cells and compare the results to current tests being done. Then, we hope to develop treatments that will target these factors. Principal Investigator: Dr. Sean Sachdev Current Clinical Trials Participate in a Trial What are Clinical Trials? Previous research has found that this ongoing pain may in part be caused by problems in the way the brain processes pain signals. NCT Number:NCT03801876 Participants will complete a total of 3 study visits (baseline, 3 months and 12 months). Clinical Trial #: E4512 Contact: Research Office 630.933.7820 Principal Investigator: Dr. Ferris Contact: Research Office 630.933.7820 NCT Number: NCT04137107 Northwestern Medicine investigators have shown that inhibiting a mutated gene can reduce seizure activity in adult-type diffuse gliomas, according to a study published in the Journal of Clinical Investigation.. Adulttype diffuse gliomas are the most common malignant tumors arising in the central nervous system, affecting six in 100,000 worldwide, according to the National Institutes of Health. This study is recruiting patients whose medical tests show they have heart failure, and whose doctors have determined that they would benefit from an insertable cardiac monitor (ICM). Learn more at Clinicaltrials.gov, Study: A Phase 1-2 Dose-Escalation and Expansion Study of ST101 in Patients with Advanced Unresectable and Metastatic Solid Tumors This study will see if two study drugs (fish oil and losartan, a commonly used blood pressure medicine) have an effect on walking ability.. Clinical Trial #: NRG-GU010 Mayo Clinic Cancer Center. This study has two phases. These women may be exposed to the side effects of their treatment without benefit. Learn more at Clinicaltrials.gov, Study: Effective Quadruplet Utilization After Treatment Evaluation (EQUATE): A Randomized Phase 3 Trial for Newly Diagnosed Multiple Myeloma Not Intended for Early Autologous Transplantation At each study visit, participants will have a physical exam, have blood drawn, answer questionnaires, and undergo quantitative sensory testing to assess responses to pressure and coldness. Previous studies have shown that cocoa may improve blood flow, improve cardiovascular health, and improve muscle function and strength. Clinical Trial #: GU003-10 Contact: Research Office 630.933.7820 https://acknowledgments.alliancefound.org . Contact: Research Office 630.933.7820 The goal of this trial is to evaluate the safety and effectiveness of the Study Device with Optimal Medical Therapy (OMT) compared to OMT alone in the study of subjects with severe or greater tricuspid regurgitation. Age > 18 years at time of referral, AND. Clinical Trial #: EA4151 Hosted by Provost Kathleen Hagerty, "The New Frontiers of Biomedical Science and Biomedical Engineering" explored wide-ranging matters related to improving the quality of human life, including advances in artificial intelligence (AI), new approaches to treating cancer, the quest for longevity, the potential of regenerative medicine, and the . Have a confirmed diagnosis of systemic sclerosis (meeting the 2013 SSc ACR/EULAR criteria), 3. Clinical Trial #: EA3191 Contact: Research Office 630.933.7820 Though South Asians represent over one-quarter of the world's population, there are This study is . Inclusion criteria for CKD: eGFR 20-60 ml/min/1.73m2 on stable doses of diuretics and/or angiotensin converting enzyme inhibitor or angiotensin receptor blocker, unless contraindicated. 312-908-5250. cancer@northwestern.edu NCT Number: NCT03775265 Learn more at Clinicaltrials.gov, Study: A phase 1/1b adaptive dose escalation study of mycophenolate mofetil (MMF) in combination with standard of care for patients with glioblastoma episodes. Clinical Trial #: NRG-GY026 NCT Number: NCT03937635 Establishing in 1991 and maintained by Northwestern University, the Chicago Lupus Database (CLD) is a registry of individuals with lupus who are willing to be contacted about future lupus research studies for which they might be eligible. AF may be treated with medicines, electrical shock(cardioversion), or the ablation for which the patient has been scheduled. Principal Investigator: Dr. Ami Shah The safety and tolerability of investigative study drug IMB-1018972 is being studied in patients with non-obstructive hypertrophic cardiomyopathy. BRCA1 and BRCA2 are human genes that produce tumor suppressor proteins. Principal Investigator: Dr. Gharzai Northwestern University Feinberg School of Medicine. A germ cell tumor is a type of cancer that occurs in the ovaries (for females) or the testes (for males). : A Platform Trial for Women with Recurrent or Persistent Endometrial Cancer Principal Investigator: Dr. Hartsell NCT Number: NCT04239573 Jagust shared an overview of current research into the link between the protein tau, amyloid beta peptides in the brain, and the progression of Alzheimer's Disease. Of genes to help us these medications have been demonstrated to have great promise treating! 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